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Article

Synthesis and biological characterization of B-ring amino analogues of potent benzothiadiazine hepatitis C virus polymerase inhibitors.

Journal of medicinal chemistry - 28 May 2009

Randolph John T, Flentge Charles A, Huang Peggy P, Hutchinson Douglas K, Klein Larry L, Lim Hock B, Mondal Rubina, Reisch Thomas, Montgomery Debra A, Jiang Wen W, Masse Sherie V, Hernandez Lisa E, Henry Rodger F, Liu Yaya, Koev Gennadiy, Kati Warren M, Stewart Kent D, Beno David W A, Molla Akhteruzzaman, Kempf Dale J

Abstract excerpt

Benzothiadiazine inhibitors of the HCV NS5B RNA-dependent RNA polymerase are an important class of non-nucleoside inhibitors that have received considerable attention in the search for novel HCV therapeutics. Research in our laboratories has identified a novel series of tetracyclic benzothiadiazine inhibitors of HCV polymerase bearing a benzylamino substituent on the B-ring. Compounds in this series exhibit...

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Identifiers

PMID: 19402666
DOI: 10.1021/jm801485z

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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