3-(1,1-dioxo-2H-(1,2,4)-benzothiadiazin-3-yl)-4-hydroxy-2(1H)-quinolinones, potent inhibitors of hepatitis C virus RNA-dependent RNA polymerase.

doi:10.1021/jm050855s

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3-(1,1-dioxo-2H-(1,2,4)-benzothiadiazin-3-yl)-4-hydroxy-2(1H)-quinolinones, potent inhibitors of hepatitis C virus RNA-dependent RNA polymerase.

Journal of medicinal chemistry - 9 Feb 2006

Tedesco Rosanna, Shaw Antony N, Bambal Ramesh, Chai Deping, Concha Nestor O, Darcy Michael G, Dhanak Dashyant, Fitch Duke M, Gates Adam, Gerhardt Warren G, Halegoua Dina L, Han Chao, Hofmann Glenn A, Johnston Victor K, Kaura Arun C, Liu Nannan, Keenan Richard M, Lin-Goerke Juili, Sarisky Robert T, Wiggall Kenneth J, Zimmerman Michael N, Duffy Kevin J

Abstract excerpt

Recently, we disclosed a new class of HCV polymerase inhibitors discovered through high-throughput screening (HTS) of the GlaxoSmithKline proprietary compound collection. This interesting class of 3-(1,1-dioxo-2H-1,2,4-benzothiadiazin-3-yl)-4-hydroxy-2(1H)-quinolinones potently inhibits HCV polymerase enzymatic activity and inhibits the ability of the subgenomic HCV replicon to replicate in Huh-7 cells. This...

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PMID: 16451063
DOI: 10.1021/jm050855s

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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