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Hepatitis C NS5B polymerase inhibitors: 4,4-Dialkyl-1-hydroxy-3-oxo-3,4-dihydronaphthalene-3-yl benzothiadiazine derivatives.

Bioorganic & medicinal chemistry letters - 15 Jul 2008

Hutchinson Douglas K, Rosenberg Teresa, Klein Larry L, Bosse Todd D, Larson Daniel P, He Wenping, Jiang Wen W, Kati Warren M, Kohlbrenner William E, Liu Yaya, Masse Sherie V, Middleton Tim, Molla Akhteruzzaman, Montgomery Debra A, Beno David W A, Stewart Kent D, Stoll Vincent S, Kempf Dale J

Abstract excerpt

4,4-Dialkyl-1-hydroxy-3-oxo-3.4-dihydronaphthalene-3-yl benzothiadiazine derivatives were synthesized and evaluated as inhibitors of genotypes 1a and 1b HCV NS5B polymerase. A number of these compounds exhibited potent activity against genotypes 1a and 1b HCV polymerase in both enzymatic and cell...

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PMID: 18599294
DOI: 10.1016/j.bmcl.2008.06.043

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18599294-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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