Article
Synthesis and biological activity of heteroaryl 3-(1,1-dioxo-2H-(1,2,4)-benzothiadizin-3-yl)-4-hydroxy-2(1H)-quinolinone derivatives as hepatitis C virus NS5B polymerase inhibitors.
Bioorganic & medicinal chemistry letters - 1 Aug 2009
Tedesco Rosanna, Chai Deping, Darcy Michael G, Dhanak Dashyant, Fitch Duke M, Gates Adam, Johnston Victor K, Keenan Richard M, Lin-Goerke Juili, Sarisky Robert T, Shaw Antony N, Valko Klara L, Wiggall Kenneth J, Zimmerman Michael N, Duffy Kevin J
Abstract excerpt
Modification of the benzo rings of 3-(1,1-dioxo-2H-(1,2,4)-benzothiadiazin-3-yl)-4-hydroxy-2(1H)-quinolinones into heteroaromatic systems was investigated to enhance physicochemical properties and potency profile of this class of inhibitors. The synthesis and biological activity of the derived compounds is discussed.
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