Article
Inhibitors of HCV NS5B polymerase: synthesis and structure-activity relationships of N-1-benzyl and N-1-[3-methylbutyl]-4-hydroxy-1,8-naphthyridon-3-yl benzothiadiazine analogs containing substituents on the aromatic ring.
Bioorganic & medicinal chemistry letters - 15 Jul 2006
Rockway Todd W, Zhang Rong, Liu Dachun, Betebenner David A, McDaniel Keith F, Pratt John K, Beno David, Montgomery Debra, Jiang Wen W, Masse Sherie, Kati Warren M, Middleton Tim, Molla Akhteruzzaman, Maring Clarence J, Kempf Dale J
Abstract excerpt
A series of non-nucleoside HCV NS5B polymerase inhibitors based on the N-1-benzyl or N-1-[3-methylbutyl]-4-hydroxy-1,8-naphthyridon-3-yl benzothiadiazine core substituted in the D-ring aromatic moiety have been prepared and evaluated. Aromatic substituents extending from position 7 of the D-ring...
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