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Article

Potential therapeutic targets for chordoma: PI3K/AKT/TSC1/TSC2/mTOR pathway

28 Apr 2009

Abstract excerpt

Chordomas are radio- and chemo-resistant tumours and metastasise in as many as 40% of patients. The aim of this study was to identify potential molecular targets for the treatment of chordoma. In view of the reported association of chordoma and tuberous sclerosis complex syndrome, and the available therapeutic agents against molecules in the PI3K/AKT/TSC1/TSC2/mTOR pathway, a tissue microarray of 50 chordoma...

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PMID: 19401700
DOI: 10.1038/sj.bjc.6605019

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