Article
A zebrafish model of chordoma initiated by notochord-driven expression of HRASV12.
Disease models & mechanisms - 1 Jul 2014
Burger Alexa, Vasilyev Aleksandr, Tomar Ritu, Selig Martin K, Nielsen G Petur, Peterson Randall T, Drummond Iain A, Haber Daniel A
Abstract excerpt
Chordoma is a malignant tumor thought to arise from remnants of the embryonic notochord, with its origin in the bones of the axial skeleton. Surgical resection is the standard treatment, usually in combination with radiation therapy, but neither chemotherapeutic nor targeted therapeutic approaches have demonstrated success. No animal model and only few chordoma cell lines are available for preclinical drug...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.