EGFR-dependent and independent activation of Akt/mTOR cascade in bone and soft tissue tumors.

doi:10.1038/modpathol.2009.104

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Article

EGFR-dependent and independent activation of Akt/mTOR cascade in bone and soft tissue tumors.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Oct 2009

Dobashi Yoh, Suzuki Shioto, Sato Eiichi, Hamada Yoshiki, Yanagawa Takashi, Ooi Akishi

Abstract excerpt

To gain the insight into the involvement of signaling mediated by the mammalian target of rapamycin (mTOR) in the phenotype and biological profiles of tumors and tumor-like lesions of the bone and soft tissue, we analyzed the expression and phosphorylation (activation) of mTOR and its correlation with the status of upstream and downstream modulator proteins Akt, p70S6-kinase (S6K), and eukaryotic initiation...

Topics

Adaptor Proteins, Signal Transducing
Bone Neoplasms
Cell Cycle Proteins
Cell Proliferation
Enzyme Activation
ErbB Receptors
Humans
Immunoblotting
Immunohistochemistry
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neoplasm Staging

Phosphoproteins

Phosphorylation

Prognosis

Protein Kinases

Proto-Oncogene Proteins c-akt

Ribosomal Protein S6 Kinases, 70-kDa

Signal Transduction

Source

Open in PubMed

Identifiers

PMID: 19648884
DOI: 10.1038/modpathol.2009.104

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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