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Article

The role of epidermal growth factor receptor in chordoma pathogenesis: a potential therapeutic target.

The Journal of pathology - 1 Feb 2011

Shalaby Asem, Presneau Nadège, Ye Hongtao, Halai Dina, Berisha Fitim, Idowu Bernadine, Leithner Andreas, Liegl Bernadette, Briggs Timothy R W, Bacsi Krisztian, Kindblom Lars-Gunnar, Athanasou Nicholas, Amary Maria Fernanda, Hogendoorn Pancras C W, Tirabosco Roberto, Flanagan Adrienne M

Abstract excerpt

Chordoma, the molecular hallmark of which is T (brachyury), is a rare malignant bone tumour with a high risk of local recurrence and a tumour from which metastatic disease is a common late event. Currently, there is no effective drug therapy for treating chordomas, although there is evidence that...

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Identifiers

PMID: 21171079
DOI: 10.1002/path.2818

Genes

EGFR
BRAF
HRAS
KRAS
NRAS
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21171079-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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The role of epidermal growth factor receptor in chordoma pathogenesis: a potential therapeutic target.PMID 21171079Read ↗

Unraveling molecular advancements in chordoma tumorigenesis and treatment response: a review of scientific discoveries and clinical implicationsSemantic proximity Read ↗

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Role of the transcription factor T (brachyury) in the pathogenesis of sporadic chordoma: a genetic and functional-based study.Semantic proximity Read ↗

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Identification of the Different Roles and Potential Mechanisms of T Isoforms in the Tumor Recurrence and Cell Cycle of ChordomasSemantic proximity Read ↗

Recent advances in understanding and managing chordomas: an updateSemantic proximity Read ↗

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