Article
The role of epidermal growth factor receptor in chordoma pathogenesis: a potential therapeutic target.
The Journal of pathology - 1 Feb 2011
Shalaby Asem, Presneau Nadège, Ye Hongtao, Halai Dina, Berisha Fitim, Idowu Bernadine, Leithner Andreas, Liegl Bernadette, Briggs Timothy R W, Bacsi Krisztian, Kindblom Lars-Gunnar, Athanasou Nicholas, Amary Maria Fernanda, Hogendoorn Pancras C W, Tirabosco Roberto, Flanagan Adrienne M
Abstract excerpt
Chordoma, the molecular hallmark of which is T (brachyury), is a rare malignant bone tumour with a high risk of local recurrence and a tumour from which metastatic disease is a common late event. Currently, there is no effective drug therapy for treating chordomas, although there is evidence that some patients respond to the empirical use of epidermal growth factor receptor (EGFR) antagonists. The aim of this...
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