Potential role of AKT/mTOR signalling proteins in hairy cell leukaemia: association with BRAF/ERK activation and clinical outcome.

doi:10.1038/srep21252

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Article

Potential role of AKT/mTOR signalling proteins in hairy cell leukaemia: association with BRAF/ERK activation and clinical outcome.

Scientific reports - 19 Feb 2016

Lakiotaki Eleftheria, Levidou Georgia, Angelopoulou Maria K, Adamopoulos Christos, Pangalis Gerassimos, Rassidakis George, Vassilakopoulos Theodoros, Gainaru Gabriella, Flevari Pagona, Sachanas Sotirios, Saetta Angelica A, Sepsa Athanasia, Moschogiannis Maria, Kalpadakis Christina, Tsesmetzis Nikolaos, Milionis Vassilios, Chatziandreou Ilenia, Thymara Irene, Panayiotidis Panayiotis, Dimopoulou Maria, Plata Eleni, Konstantopoulos Konstantinos, Patsouris Efstratios, Piperi Christina, Korkolopoulou Penelope

Abstract excerpt

The potential role of AKT/mTOR signalling proteins and its association with the Raf-MEK-ERK pathway was investigated in hairy cell leukaemia (HCL). BRAFV600E expression and activated forms of AKT, mTOR, ERK1/2, p70S6k and 4E-BP1 were immunohistochemically assessed in 77 BM biopsies of HCL patients and correlated with clinicopathological and BM microvascular characteristics, as well as with c-Caspase-3 levels in...

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PMID: 26893254
DOI: 10.1038/srep21252
PMCID: PMC4759548

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BRAF

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