Article
Application of homozygosity haplotype analysis to genetic mapping with high-density SNP genotype data.
PloS one - 1 Jan 2009
Jiang Haiyan, Orr Andrew, Guernsey Duane L, Robitaille Johane, Asselin Géraldine, Samuels Mark E, Dubé Marie-Pierre
Abstract excerpt
BACKGROUND: In families segregating a monogenic genetic disorder with a single disease gene introduction, patients share a mutation-carrying chromosomal interval with identity-by-descent (IBD). Such a shared chromosomal interval or haplotype, surrounding the actual pathogenic mutation, is typically detected and defined by multipoint linkage and phased haplotype analysis using microsatellite or SNP genotype data....
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