Article
Homozygosity haplotype allows a genomewide search for the autosomal segments shared among patients.
American journal of human genetics - 1 Jun 2007
Miyazawa Hitoshi, Kato Masaaki, Awata Takuya, Kohda Masakazu, Iwasa Hiroyasu, Koyama Nobuyuki, Tanaka Tomoaki, Huqun, Kyo Shunei, Okazaki Yasushi, Hagiwara Koichi
Abstract excerpt
A promising strategy for identifying disease susceptibility genes for both single- and multiple-gene diseases is to search patients' autosomes for shared chromosomal segments derived from a common ancestor. Such segments are characterized by the distinct identity of their haplotype. The methods and algorithms currently available have only a limited capability for determining a high-resolution haplotype...
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