Article
Oxidative stress response elicited by mitochondrial dysfunction: implication in the pathophysiology of aging.
Experimental biology and medicine (Maywood, N.J.) - 1 May 2013
Wang Chih-Hao, Wu Shi-Bei, Wu Yu-Ting, Wei Yau-Huei
Abstract excerpt
Under normal physiological conditions, reactive oxygen species (ROS) serve as 'redox messengers' in the regulation of intracellular signalling, whereas excess ROS may induce irreversible damage to cellular components and lead to cell death by promoting the intrinsic apoptotic pathway through mitochondria. In the aging process, accumulation of mitochondria DNA mutations, impairment of oxidative phosphorylation as...
Topics
- Animals
- Apoptosis
- Autophagy
- DNA, Mitochondrial
- Humans
- Longevity
- Mitochondria
- Mitophagy
- Mutation
- Oxidative Stress
- Protein Processing, Post-Translational