Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The functionality of African-specific variants in the TGFB1 regulatory region and their potential role in HIVAN.

Clinical and experimental nephrology - 1 Aug 2018

Nel M, Buys J-M, Botha F C J, Wearne N, Prince S, Heckmann J M

Abstract excerpt

BACKGROUND: Transcription of transforming growth factor beta-1 (TGF-β1) is regulated by a polymorphic promoter region containing African-specific single nucleotide polymorphisms (SNPs). Some of these SNPs have higher frequencies among Southern Africans compared to other African populations and their functionality has only been partially studied. Due to the high prevalence of HIV-associated nephropathy (HIVAN) in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Africa
Share to Cell Line
Share to Fibroblasts

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Haplotypes

Share to Kidney

Share to Polymorphism, Single Nucleotide

Share to Regulatory Sequences, Nucleic Acid

Share to Transforming Growth Factor beta1

Source

Identifiers

PMID: 29204904
DOI: 10.1007/s10157-017-1516-4

Genes

TGFB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The functionality of African-specific variants in the TGFB1 regulatory region and their potential role in HIVAN.PMID 29204904Read ↗

HIV-associated nephropathy: Protocol and rationale for an exploratory genotype-phenotype study in a sub-Saharan African population.Semantic proximity Read ↗

APOL1 risk variants and the development of HIV-associated nephropathy.Semantic proximity Read ↗

HIV nephropathy and the Duffy antigen/receptor for Chemokines in African Americans.Semantic proximity Read ↗

Association of Genetic Polymorphisms of TGF-β1, HMOX1, and APOL1 With CKD in Nigerian Patients With and Without HIV.Semantic proximity Read ↗

Pathogenesis of HIV-associated nephropathy in children and adolescents: taking a hard look 40 years later in the era of gene-environment interactions.Semantic proximity Read ↗

HIV-associated nephropathy in African Americans11The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the U.S. Government. The publisher or recipient acknowledges right of the U.S. Government to retain a nonexclusive, royalty-free license in and to any copyright covering the article.Semantic proximity Read ↗

Frequency variation among sub-Saharan populations in virus restriction gene, BST-2 proximal promoter polymorphisms: implications for HIV-1 prevalence differences among African countries.Semantic proximity Read ↗

Allelic diversity in the TGFB1 regulatory region: characterization of novel functional single nucleotide polymorphisms.Semantic proximity Read ↗

Host factors predisposing to kidney disease in people with HIV.Semantic proximity Read ↗

APOL1 Risk Variants Are Strongly Associated with HIV-Associated Nephropathy in Black South Africans.Semantic proximity Read ↗

HIV-associated nephropathy: pathogenesisSemantic proximity Read ↗

Molecular Mechanisms of Injury in HIV-Associated NephropathySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.