Article
Common inherited mitochondrial DNA mutations and nucleoside reverse transcriptase inhibitor-induced severe hyperlactataemia in HIV-infected adults: an exploratory study.
Antiviral therapy - 1 Jan 2012
Arenas-Pinto Alejandro, Weller Ian, Ekong Rosemary, Grant Alison, Karstaedt Alan, Reiss Peter, Telisinghe Lilanganee, Weber Rainer, Bolhaar Martine, Bradman Neil, Ingram Catherine
Abstract excerpt
BACKGROUND: Genetic predisposition to dideoxynucleoside-induced mitochondrial dysfunction might be related to mitochondrial DNA (mtDNA) polymorphisms. Severe hyperlactataemia is probably the best model to assess such a predisposition. METHODS: For this exploratory study in White European and Black African HIV-infected adults, hypervariable region 1 of mtDNA samples from peripheral blood mononuclear cells or...
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