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Functional Impact of Genomic Complexity on the Transcriptome of Multiple Myeloma

15 Sept 2021

Abstract excerpt

Abstract Purpose: Multiple myeloma is a biologically heterogenous plasma-cell disorder. In this study, we aimed at dissecting the functional impact on transcriptome of gene mutations, copy-number abnormalities (CNA), and chromosomal rearrangements (CR). Moreover, we applied a geno-transcriptomic approach to identify specific biomarkers for personalized treatments. Experimental Design: We analyzed 514 newly...

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PMID: 34526359
DOI: 10.1158/1078-0432.ccr-20-4366

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