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Molecular characterization of human multiple myeloma cell lines by integrative genomics: Insights into the biology of the disease

14 Dec 2006

Abstract excerpt

To investigate the patterns of genetic lesions in a panel of 23 human multiple myeloma cell lines (HMCLs), we made a genomic integrative analysis involving FISH, and both gene expression and genome-wide profiling approaches. The expression profiles of the genes targeted by the main IGH translocations showed that the WHSC1/MMSET gene involved in t(4;14)(p16;q32) was expressed at different levels in all of the...

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PMID: 17171682
DOI: 10.1002/gcc.20404

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