Article
Loss of caveolin-3 induces a lactogenic microenvironment that is protective against mammary tumor formation.
The American journal of pathology - 1 Feb 2009
Sotgia Federica, Casimiro Mathew C, Bonuccelli Gloria, Liu Manran, Whitaker-Menezes Diana, Er Ozlem, Daumer Kristin M, Mercier Isabelle, Witkiewicz Agnieszka K, Minetti Carlo, Capozza Franco, Gormley Michael, Quong Andrew A, Rui Hallgeir, Frank Philippe G, Milliman Janet N, Knudsen Erik S, Zhou Jie, Wang Chenguang, Pestell Richard G, Lisanti Michael P
Abstract excerpt
Here, we show that functional loss of a single gene is sufficient to confer constitutive milk protein production and protection against mammary tumor formation. Caveolin-3 (Cav-3), a muscle-specific caveolin-related gene, is highly expressed in muscle cells. We demonstrate that Cav-3 is also expressed in myoepithelial cells within the mammary gland. To determine whether genetic ablation of Cav-3 expression...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.