Article
Reassessing the impact of donor HLA-C genotype on long-term liver transplant survival.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons - 1 Jul 2009
Tran T H, Middleton D, Döhler B, Scherer S, Meenagh A, Sleator C, Opelz G
Abstract excerpt
HLA-C is the major inhibitory ligand for killer immunoglobulin-like receptors (KIRs) that are expressed on natural killer (NK) cells. Based on their KIR specificity, HLA-C alleles can be divided into two groups, termed HLA-C1 and HLA-C2. Donor HLA-C group has recently been identified by Hanvesakul et al. (Am J Transplant 2008) as a critical determinant of clinical outcome following liver transplantation:...
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