Article
Influence of the immunogenetic KIR and HLA systems on long-term renal transplant outcome.
Annals of transplantation - 13 Nov 2013
La Manna Gaetano, Corsini Serena, Iannelli Sandra, Cappuccilli Maria Laura, Comai Giorgia, Iorio Mario, Todeschini Paola, Carretta Elisa, Scolari Maria Piera, Bontadini Andrea, Stefoni Segio
Abstract excerpt
BACKGROUND: Numerous studies have established the importance of innate immunity, particularly natural killer (NK) cells, in transplantation tolerance. NK cells express killer cell immunoglobulin-like receptors (KIRs) on their surface. By recognizing and binding major histocompatibility complex class I antigens, KIRs prevent autologous cell killing and promote lysis of non-self antigen-presenting cells. This study...
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