Article
The basal phenotype of BRCA1-related breast cancer: past, present and future.
Cell cycle (Georgetown, Tex.) - 1 May 2006
Tischkowitz Marc D, Foulkes William D
Abstract excerpt
Many BRCA1-related tumors have a distinct histological characteristics which together have been called "basal-like." Typically such tumors are ER-, HER2- and express cytokeratin 5/6, cytokeratin 8/18, EGFR and vimentin. These characteristics can be used to predict which breast cancers are most likely to be associated with germline BRCA1 mutations which has important implications for breast pathologists. Moreover,...
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