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Article

Germline BRCA1 mutations and a basal epithelial phenotype in breast cancer.

Journal of the National Cancer Institute - 1 Oct 2003

Foulkes William D, Stefansson Ingunn M, Chappuis Pierre O, Bégin Louis R, Goffin John R, Wong Nora, Trudel Michel, Akslen Lars A

Abstract excerpt

A basal epithelial phenotype is found in not more than 15% of all invasive breast cancers. Microarray studies have shown that this phenotype is associated with breast cancers that express neither estrogen receptor (ER) nor erbB-2 (HER2/neu) (i.e., ER/erbB-2-negative tumors). The ER/erbB-2- negative phenotype is also found in breast cancers occurring in BRCA1 mutation carriers (i.e., BRCA1-related breast cancers)....

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 14519755
DOI: 10.1093/jnci/djg050

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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