Article
Presence of HIV-1 R5 viruses in cerebrospinal fluid even in patients harboring R5X4/X4 viruses in plasma.
Journal of acquired immune deficiency syndromes (1999) - 1 May 2009
Soulié Cathia, Tubiana Roland, Simon Anne, Lambert-Niclot Sidonie, Malet Isabelle, Canestri Ana, Brunet Christel, Murphy Robert, Katlama Christine, Calvez Vincent, Marcelin Anne-Geneviève
Abstract excerpt
BACKGROUND: HIV-1 viruses have the ability to use CCR5 or CXCR4 coreceptors either solely (R5 or X4) or in combination (R5X4). The CCR5 antagonists block HIV entry into the cell and are specifically active against HIV-1 R5 strains. The objectives of this study were to investigate the predicted tropism of viruses present in paired cerebrospinal fluid (CSF) and plasma in a group of 22 HIV-1-infected patients with...
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