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Membrane array–based differential profiling of platelets during storage for 52 miRNAs associated with apoptosis

31 Mar 2009

Abstract excerpt

BACKGROUND: Enucleated platelets (PLTs) utilize posttranscriptional gene (mRNA) regulation (PTGR) for their normal morphologic and physiologic functions, which are altered in their ex vivo storage, also collectively referred to as storage lesions. While cellular micro-RNAs (miRNAs) play a significant role in posttranscriptional gene (mRNA) regulation by binding to their target mRNAs, comprehensive analysis of...

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PMID: 19389023
DOI: 10.1111/j.1537-2995.2009.02140.x

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