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Analysis of Argonaute 2–microRNA complexes in ex vivo stored red blood cells

20 Sept 2017

Abstract excerpt

BACKGROUND: Human enucleated mature red blood cells (RBCs) contain both mature microRNAs (miRNAs) and mRNAs, and we have previously correlated RBC storage lesion processes such as eryptosis, adenosine 5'-triphosphate loss, and RBC indices with differentially expressed miRNAs. Here we have characterized Argonaute 2 (AGO2)-miRNA complexes in stored mature RBCs as a first step toward understanding their role, if...

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PMID: 28940437
DOI: 10.1111/trf.14325

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