Article
Platelet Molecular Maturation Links Platelet Aging and the Platelet Storage Lesion
2026-02-05
Abstract excerpt
<h4>ABSTRACT</h4> Human platelets change over their 7–10 day lifespan, yet the molecular mechanisms underlying platelet aging remain poorly defined. Using two independent RNA sequencing datasets of fluorescence-activated cell sorted young and old human platelets, we developed a unified transcriptomic model to characterize RNA metabolism across the platelet lifespan, which we termed platelet molecular maturation....
Topics
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- Antiplatelet Therapy and Cardiovascular Diseases
- Blood groups and transfusion
- Cancer Genomics and Diagnostics
- Cancer-related molecular mechanisms research
- Extracellular vesicles in disease
- Immune Cell Function and Interaction
- Platelet Disorders and Treatments
- Venous Thromboembolism Diagnosis and Management
Identifiers and source
- Literature Corpus work
- 9a61aea1-43d3-539d-9b0c-b71ea76cf221
- DOI
- 10.64898/2026.02.03.703379