Article
Correlation of polymorphism C3435T of the MDR-1 gene and the response of primary chemotherapy in women with locally advanced breast cancer.
Genetics and molecular research : GMR - 19 Feb 2008
Rodrigues F F O, Santos R E, Melo M B, Silva M A L G, Oliveira A L, Rozenowicz R L, Ulson L B, Aoki T
Abstract excerpt
Primary chemotherapy is a useful strategy for the treatment of locally advanced breast cancer and therefore allows in vivo evaluation of the action of cytotoxic drugs and the possibility of accomplishing conservative breast surgeries, as well as the early treatment of metastasis. Mechanisms of resistance to the drugs include the action of protein associated with the efflux of drugs from the intracellular...
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