Article
Effect of MDR1 polymorphism on multidrug resistance expression in breast cancer patients.
Genetics and molecular research : GMR - 12 Jan 2010
Taheri M, Mahjoubi F, Omranipour R
Abstract excerpt
One of the limitations in the treatment of cancer patients with chemotherapy is the development of multidrug resistance (MDR). A well-known mechanism responsible for drug resistance is over-expression of ABC-transporter genes such as MDR1. This gene encodes p-glycoprotein (P-gp), a transmembrane glycoprotein that transports many hydrophobic substrates and anti-cancer drugs out of the cell. MDR1 gene polymorphisms...
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