Article
Characterization of a novel splicing variant in the RAPTOR gene.
Mutation research - 9 Mar 2009
Sun Chang, Southard Catherine, Di Rienzo Anna
Abstract excerpt
The mammalian target of rapamycin (mTOR) plays an essential role in the regulation of cell growth, proliferation and apoptosis. Raptor, the regulatory associated protein of mTOR, is an important member in this signaling pathway. In the present report,we identified and characterized a novel splicing variant of this gene, RAPTOR v2, in which exons 14-17, 474 bp in total, are omitted from the mRNA. This deletion...
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