Article
Relevance of gamma interferon, tumor necrosis factor alpha, and interleukin-10 gene polymorphisms to susceptibility to Mediterranean spotted fever.
Clinical and vaccine immunology : CVI - 1 Jun 2009
Forte Giusi Irma, Scola Letizia, Misiano Gabriella, Milano Salvatore, Mansueto Pasquale, Vitale Giustina, Bellanca Fiamma, Sanacore Maria, Vaccarino Loredana, Rini Giovan Battista, Caruso Calogero, Cillari Enrico, Lio Domenico, Mansueto Serafino
Abstract excerpt
The acute phase of Mediterranean spotted fever (MSF) is characterized by dramatic changes in cytokine production patterns, clearly indicating their role in the immunomodulation of the response against the microorganism, and the differences in cytokine production seem to influence the extent and severity of the disease. In this study, the single nucleotide polymorphisms (SNPs) of tumor necrosis factor alpha...
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