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Article

Obligate ordered binding of human lactogenic cytokines.

The Journal of biological chemistry - 25 Jun 2010

Voorhees Jeffery L, Brooks Charles L

Abstract excerpt

Class 1 cytokines bind two receptors to create an active heterotrimeric complex. It has been argued that ligand binding to their receptors is an ordered process, but a structural mechanism describing this process has not been determined. We have previously described an obligate ordered binding mechanism for the human prolactin/prolactin receptor heterotrimeric complex. In this work we expand this conceptual...

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Identifiers

PMID: 20427283
DOI: 10.1074/jbc.M109.084988
PMCID: PMC2888414

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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