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Article

A genetic variant of BAFF is associated with the risk of lymphoma in Sjögren disease.

Annals of the rheumatic diseases - 1 Jun 2026

Beydon Maxime, Dulin Marie, Ly Bineta, Verstuyft Céline, Cardoso Allison, Juge Pierre Antoine, Dieudé Philippe, Lessard Christopher J, Khatri Bhuwan, Radziszewski Marcin, Guern Véronique Le, Gottenberg Jacques Eric, Seror Raphaele, Mariette Xavier, Nocturne Gaetane

Abstract excerpt

OBJECTIVES: B-cell activating factor (BAFF) of the Tumors Necrosis Factor (TNF) family is involved in the pathogenesis of Sjögren's disease (SjD). A functional variant (BAFF variant [BAFF-var]) of the BAFF gene (TNFSF13B), leading to increased levels of BAFF, has been described. The aim of this study was to investigate the association between BAFF-var and clinical phenotype and risk of SjD. METHODS: A...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41539891
DOI: 10.1016/j.ard.2025.12.010
PMCID: PMC13531349

Genes

EFS
TNF
TNFSF13B

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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