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Article

Genetic variation in tumor necrosis factor and the nuclear factor-kappaB canonical pathway and risk of non-Hodgkin's lymphoma.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Nov 2008

Cerhan James R, Liu-Mares Wen, Fredericksen Zachary S, Novak Anne J, Cunningham Julie M, Kay Neil E, Dogan Ahmet, Liebow Mark, Wang Alice H, Call Timothy G, Habermann Thomas M, Ansell Stephen M, Slager Susan L

Abstract excerpt

Non-Hodgkin's lymphoma (NHL) is a cancer closely associated with immune function, and the tumor necrosis factor (TNF) G-308A promoter polymorphism, which influences immune function and regulation, was recently reported by the InterLymph Consortium to be associated with NHL risk. TNF signaling activates the nuclear factor-kappaB (NF-kappaB) canonical pathway, leading to transcriptional activation of multiple genes...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18990758
DOI: 10.1158/1055-9965.EPI-08-0536
PMCID: PMC2735864

Genes

TNF
LTA
NFKB1
CHUK
IKBKB
REL
RIPK1
TRADD
TRAF2
TRAF5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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