Article
Common gene variants in the tumor necrosis factor (TNF) and TNF receptor superfamilies and NF-kB transcription factors and non-Hodgkin lymphoma risk.
PloS one - 1 Jan 2009
Wang Sophia S, Purdue Mark P, Cerhan James R, Zheng Tongzhang, Menashe Idan, Armstrong Bruce K, Lan Qing, Hartge Patricia, Kricker Anne, Zhang Yawei, Morton Lindsay M, Vajdic Claire M, Holford Theodore R, Severson Richard K, Grulich Andrew, Leaderer Brian P, Davis Scott, Cozen Wendy, Yeager Meredith, Chanock Stephen J, Chatterjee Nilanjan, Rothman Nathaniel
Abstract excerpt
BACKGROUND: A promoter polymorphism in the pro-inflammatory cytokine tumor necrosis factor (TNF) (TNF G-308A) is associated with increased non-Hodgkin lymphoma (NHL) risk. The protein product, TNF-alpha, activates the nuclear factor kappa beta (NF-kappaB) transcription factor, and is critical for inflammatory and apoptotic responses in cancer progression. We hypothesized that the TNF and NF-kappaB pathways are...
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