Article
Germline variation in apoptosis pathway genes and risk of non-Hodgkin's lymphoma.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Nov 2010
Kelly Jennifer L, Novak Anne J, Fredericksen Zachary S, Liebow Mark, Ansell Stephen M, Dogan Ahmet, Wang Alice H, Witzig Thomas E, Call Timothy G, Kay Neil E, Habermann Thomas M, Slager Susan L, Cerhan James R
Abstract excerpt
BACKGROUND: The t(14;18)(q32;q21) translocation is the most commonly observed chromosomal translocation in non-Hodgkin's lymphoma (NHL), resulting in constitutive Bcl-2 expression and apoptosis inhibition. In addition, germline variation in both BCL2L11 (BIM) and CASP9, known regulators of apoptosis, has recently been linked to NHL risk. We conducted a comprehensive evaluation of 36 apoptosis pathway genes with...
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