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Article

KIF5B-ALK, a novel fusion oncokinase identified by an immunohistochemistry-based diagnostic system for ALK-positive lung cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 May 2009

Takeuchi Kengo, Choi Young Lim, Togashi Yuki, Soda Manabu, Hatano Satoko, Inamura Kentaro, Takada Shuji, Ueno Toshihide, Yamashita Yoshihiro, Satoh Yukitoshi, Okumura Sakae, Nakagawa Ken, Ishikawa Yuichi, Mano Hiroyuki

Abstract excerpt

PURPOSE: EML4-ALK is a transforming fusion tyrosine kinase, several isoforms of which have been identified in lung cancer. Immunohistochemical detection of EML4-ALK has proved difficult, however, likely as a result of low transcriptional activity conferred by the promoter-enhancer region of EML4. The sensitivity of EML4-ALK detection by immunohistochemistry should be increased adequately. EXPERIMENTAL DESIGN: We...

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Source

Identifiers

PMID: 19383809
DOI: 10.1158/1078-0432.CCR-08-3248

Genes

ALK
EML4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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