Article
The use of quantitative real-time reverse transcriptase PCR for 5' and 3' portions of ALK transcripts to detect ALK rearrangements in lung cancers.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Sept 2012
Wang Rui, Pan Yunjian, Li Chenguang, Hu Haichuan, Zhang Yang, Li Hang, Luo Xiaoyang, Zhang Jie, Fang Zhaoyuan, Li Yuan, Shen Lei, Ji Hongbin, Garfield David, Sun Yihua, Chen Haiquan
Abstract excerpt
PURPOSE: Approximately 3% to 7% of non-small cell lung cancers (NSCLC) harbor an ALK fusion gene, thus defining a tumor group that may be responsive to targeted therapy. The breakpoint in ALK consistently occurs at exon 20 and EML4 or other fusion partners, thus driving a strong expression of ALK kinase domain and resulting in an unbalanced expression in 5' and 3' portions of ALK transcripts. We have developed a...
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