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Article

uPAR induces expression of transforming growth factor β and interleukin-4 in cancer cells to promote tumor-permissive conditioning of macrophages.

The American journal of pathology - 1 Dec 2014

Hu Jingjing, Jo Minji, Eastman Boryana M, Gilder Andrew S, Bui Jack D, Gonias Steven L

Abstract excerpt

Cancer cells condition macrophages and other inflammatory cells in the tumor microenvironment so that these cells are more permissive for cancer growth and metastasis. Conditioning of inflammatory cells reflects, at least in part, soluble mediators (such as transforming growth factor β and IL-4) that are released by cancer cells and alter the phenotype of cells of the innate immune system. Signaling pathways in...

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Identifiers

PMID: 25310970
DOI: 10.1016/j.ajpath.2014.08.003
PMCID: PMC4258500

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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