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Article

trans-Complementation of HBV rtM204I mutant replication by HBV wild-type polymerase.

Virology - 25 May 2009

Heipertz Richard A, Starkey Jason L, Miller Thomas G, Hu Jianming, Isom Harriet C

Abstract excerpt

The function of the hepatitis B virus (HBV) wild-type (WT) polymerase (pol) expressed alone or in the context of the intact genome when interacting with HBV rtM204I in HepG2 cells was compared. We show that WT pol expression from a packaging-defective RNA can complement defective rtM204I pol activity resulting in increased levels of HBV replicative intermediates (RI). Analysis of the genetically marked genomes...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19383566
DOI: 10.1016/j.virol.2009.03.018
PMCID: PMC3670753

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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