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Article

In vitro study of the effects of precore and lamivudine-resistant mutations on hepatitis B virus replication.

Journal of virology - 1 Apr 2007

Heipertz Richard A, Miller Thomas G, Kelley Colleen M, Delaney William E, Locarnini Stephen A, Isom Harriet C

Abstract excerpt

Understanding the consequences of mutation in the hepatitis B virus (HBV) genome on HBV replication is critical for treating chronic HBV infection. In this study, HBV replication in HepG2 cells initiated by transduction with precore (PC), rtM204I, and wild-type (wt) HBV recombinant baculoviruses was compared. The pattern and magnitude of HBV replication initiated by the PC HBV recombinant baculovirus were similar...

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Share to Baculoviridae
Share to Drug Resistance, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Viral

Share to Hepatitis B virus

Share to Lamivudine

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Share to Viral Core Proteins

Share to Virus Replication

Source

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Identifiers

PMID: 17215289
DOI: 10.1128/JVI.02341-06
PMCID: PMC1866076

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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