Article
Cis-preferential recruitment of duck hepatitis B virus core protein to the RNA/polymerase preassembly complex.
Hepatology (Baltimore, Md.) - 1 Jan 2002
von Weizsäcker Fritz, Köck Josef, Wieland Stefan, Beck Jürgen, Nassal Michael, Blum Hubert E
Abstract excerpt
Hepadnaviral replication requires the concerted action of the polymerase and core proteins to ensure selective packaging of the RNA pregenome into nucleocapsids. Virus assembly is initiated by cis-preferential binding of polymerase to the encapsidation signal straightepsilon, present on pregenomic RNA. Using the duck hepatitis B virus (DHBV) model, we analyzed how core protein is recruited to the RNA/polymerase...
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