Article
Cis-preferential recruitment of duck hepatitis B virus core protein to the RNA/polymerase preassembly complex.
Hepatology (Baltimore, Md.) - 1 Jan 2002
von Weizsäcker Fritz, Köck Josef, Wieland Stefan, Beck Jürgen, Nassal Michael, Blum Hubert E
Abstract excerpt
Hepadnaviral replication requires the concerted action of the polymerase and core proteins to ensure selective packaging of the RNA pregenome into nucleocapsids. Virus assembly is initiated by cis-preferential binding of polymerase to the encapsidation signal straightepsilon, present on pregenomic RNA. Using the duck hepatitis B virus (DHBV) model, we analyzed how core protein is recruited to the RNA/polymerase...
Topics
- Binding Sites
- Blotting, Northern
- Blotting, Southern
- Blotting, Western
- DNA, Viral
- DNA-Directed RNA Polymerases
- Dimerization
- Hepatitis B Virus, Duck
- Mutation
- Nucleocapsid
- RNA, Messenger
- RNA, Viral
- Transcription, Genetic
- Viral Core Proteins
- Virus Replication