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Article

Calcium Sensing Receptor Variants Increase Pulmonary Hypertension Susceptibility.

Hypertension (Dallas, Tex. : 1979) - 1 Jul 2022

Liu Bingxun, Wei Yun-Peng, Fan Xiaohang, Hu Xiaoyi, Chen Zeshuai, Liu Xiaoyuan, Xu Yan, Wang Lu, Wang Tao, Ruiz Matthieu, Dupuis Jocelyn, Yuan Ping, Liu Jinming, Huang Songling, Zhu Liping, Jing Zhi-Cheng, Hu Qinghua

Abstract excerpt

BACKGROUND: Pulmonary arterial hypertension is an incurable disease, in which the extracellular CaSR (calcium sensing receptor) is mechanistically important. This study was aimed to genetically link the CaSR gene and function to the disease severity. METHODS: Sanger sequencing, Sugen/hypoxia pulmonary arterial hypertension rat model, CaSR mutated rat, transcriptional reporter assay and measurement of CaSR...

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PMID: 35477244
DOI: 10.1161/HYPERTENSIONAHA.121.18399

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