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Article

Standard and generalized McDonald-Kreitman test: a website to detect selection by comparing different classes of DNA sites.

Nucleic acids research - 1 Jul 2008

Egea Raquel, Casillas Sònia, Barbadilla Antonio

Abstract excerpt

The McDonald and Kreitman test (MKT) is one of the most powerful and extensively used tests to detect the signature of natural selection at the molecular level. Here, we present the standard and generalized MKT website, a novel website that allows performing MKTs not only for synonymous and nonsynonymous changes, as the test was initially described, but also for other classes of regions and/or several loci. The...

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PMID: 18515345
DOI: 10.1093/nar/gkn337
PMCID: PMC2447769

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