Article
Retinoid receptors, transporters, and metabolizers as therapeutic targets in late onset Alzheimer disease.
Journal of cellular physiology - 1 Dec 2006
Goodman Ann B
Abstract excerpt
Vitamin A (retinoid) is required in the adult brain to enable cognition, learning, and memory. While brain levels of retinoid diminish over the course of normal ageing, retinoid deficit is greater in late onset Alzheimer disease (LOAD) brains than in normal-aged controls. This paper reviews recent evidence supporting these statements and further suggests that genes necessary for the synthesis, transport and...
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