Article
Evidence for defective retinoid transport and function in late onset Alzheimer's disease.
Proceedings of the National Academy of Sciences of the United States of America - 4 Mar 2003
Goodman Ann B, Pardee Arthur B
Abstract excerpt
The hypothesis of this article is that late onset Alzheimer's disease (AD) is influenced by the availability in brain of retinoic acid (RA), the final product of the vitamin A (retinoid) metabolic cascade. Genetic, metabolic, and environmental/dietary evidence is cited supporting this hypothesis. Significant genetic linkages to AD are demonstrated for markers close to four of the six RA receptors, RA receptor G...
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