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Article

Recent positive selection of a human androgen receptor/ectodysplasin A2 receptor haplotype and its relationship to male pattern baldness.

Human genetics - 1 Aug 2009

Hillmer Axel M, Freudenberg Jan, Myles Sean, Herms Stefan, Tang Kun, Hughes David A, Brockschmidt Felix F, Ruan Yijun, Stoneking Mark, Nöthen Markus M

Abstract excerpt

Genetic variants in the human androgen receptor gene (AR) are associated with male pattern baldness (androgenetic alopecia, AGA) in Europeans. Previous observations of long-range linkage disequilibrium at the AR locus are consistent with the hypothesis of recent positive selection. Here, we further investigate this signature and its relationship to the AGA risk haplotype. The haplotype homozygosity suggests that...

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Source

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Identifiers

PMID: 19373488
DOI: 10.1007/s00439-009-0668-z
PMCID: PMC3774421

Genes

AGA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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