Article
Androgenetic alopecia: identification of four genetic risk loci and evidence for the contribution of WNT signaling to its etiology.
The Journal of investigative dermatology - 1 Jun 2013
Heilmann Stefanie, Kiefer Amy K, Fricker Nadine, Drichel Dmitriy, Hillmer Axel M, Herold Christine, Tung Joyce Y, Eriksson Nicholas, Redler Silke, Betz Regina C, Li Rui, Kárason Ari, Nyholt Dale R, Song Kijoung, Vermeulen Sita H, Kanoni Stavroula, Dedoussis George, Martin Nicholas G, Kiemeney Lambertus A, Mooser Vincent, Stefansson Kari, Richards J Brent, Becker Tim, Brockschmidt Felix F, Hinds David A, Nöthen Markus M
Abstract excerpt
The pathogenesis of androgenetic alopecia (AGA, male-pattern baldness) is driven by androgens, and genetic predisposition is the major prerequisite. Candidate gene and genome-wide association studies have reported that single-nucleotide polymorphisms (SNPs) at eight different genomic loci are associated with AGA development. However, a significant fraction of the overall heritable risk still awaits...
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