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Article

Spatial and temporal diversity of positive selection on shared haplotypes at the PSCA locus among worldwide human populations.

Heredity - 1 Aug 2023

Iwasaki Risa L, Satta Yoko

Abstract excerpt

Selection on standing genetic variation is important for rapid local genetic adaptation when the environment changes. We report that, for the prostate stem cell antigen (PSCA) gene, different populations have different target haplotypes, even though haplotypes are shared among populations. The C-C-A haplotype, whereby the first C is located at rs2294008 of PSCA and is a low risk allele for gastric cancer, has...

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Identifiers

PMID: 37353592
DOI: 10.1038/s41437-023-00631-8
PMCID: PMC10382566

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