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Article

Combination of polymorphisms in the beta2-adrenergic receptor and nitric oxide synthase 3 genes increases the risk for hypertension.

Journal of hypertension - 1 Jul 2009

Misono Maiko, Maeda Seiji, Iemitsu Motoyuki, Nakata Yoshio, Otsuki Takeshi, Sugawara Jun, Zempo Hirofumi, Yoshizawa Mutsuko, Miyaki Asako, Kuno Shinya, Matsuda Mitsuo, Ajisaka Ryuichi

Abstract excerpt

OBJECTIVE: Hypertension is a major risk factor for cardiovascular disease. Polymorphism in the beta2-adrenergic receptor (ADRB2) and nitric oxide synthase 3 (NOS3) genes is associated with clinical cardiovascular phenotypes. The Arg16Gly and Glu298Asp polymorphisms of ADRB2 and NOS3 genes, respectively, have been reported to be associated with hypertension. We hypothesized that a combination of these two...

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Source

Identifiers

PMID: 19373110
DOI: 10.1097/HJH.0b013e32832b7ead

Genes

NOS3
ADRB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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