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Article

Glucose or Altered Ceramide Biosynthesis Mediate Oxygen Deprivation Sensitivity Through Novel Pathways Revealed by Transcriptome Analysis in Caenorhabditis elegans.

G3 (Bethesda, Md.) - 13 Oct 2016

Ladage Mary L, King Skylar D, Burks David J, Quan Daniel L, Garcia Anastacia M, Azad Rajeev K, Padilla Pamela A

Abstract excerpt

Individuals with type 2 diabetes display metabolic abnormalities, such as hyperglycemia, increased free fatty acids, insulin resistance, and altered ceramide levels, that contribute to vascular dysfunctions and compromised oxygen delivery. Caenorhabditis elegans fed a glucose-supplemented diet or with altered ceramide metabolism, due to a hyl-2 mutation, are sensitive to oxygen deprivation (anoxia). Our...

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Identifiers

PMID: 27507791
DOI: 10.1534/g3.116.031583
PMCID: PMC5068937

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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